药效团
喹啉酮
抗菌剂
抗真菌
化学
喹唑啉
组合化学
广谱
药理学
立体化学
有机化学
医学
生物
微生物学
作者
Elham Jafari,Marzieh Rahmani Khajouei,Farshid Hassanzadeh,G. H. Hakimelahi,Ghadam Ali Khodarahmi
出处
期刊:PubMed
日期:2016-04-07
卷期号:11 (1): 1-14
被引量:37
摘要
The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities. This skeleton is an important pharmacophore considered as a privileged structure. This review highlights the recent advances in the synthesis of quinazolines and quinazolinone derivatives with potent antimicrobial and cytotoxic activities.
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