抗体
糖尿病
小岛
医学
牛血清白蛋白
内科学
内分泌学
自身抗体
1型糖尿病
免疫学
作者
Atsushi Yokota,Yoshihiko Yamaguchi,Yasuo Ueda,Tomohiro Nakanishi,Nobuhiko Ikari,Shoichi Akazawa,Seibei Miyake,Shigenobu Nagataki
标识
DOI:10.1016/0168-8227(90)90047-w
摘要
Abstract
The present study was undertaken to compare the changes in islet cell antibodies (ICA), islet cell surface antibodies using rat insulinoma cells (RINr-ICSA), and anti-bovine serum albumin antibodies (BSA-Ab) in the clinical course of type 1 (insulin-dependent) diabetes. Sera were obtained from 57 patients with type 1 diabetes and 47 normal controls. ICA, RINr-ICSA and BSA-Ab were detected by an enzymatic immunohistochemical method, an indirect immunofluorescence method and an enzyme-linked immunosorbent assay, respectively. The incidence of ICA significantly decreased with the duration of diabetes: < 1 year: 56 (83%); 1–2 years: 36 (50%); 2–3 years; 26 (33%); >3 years 639 (15%). On the other hand, RINr-ICSA and BSA-Ab showed no correlation with the duration of diabetes. There was a significant positive correlation between RINr-ICSA and BSA-Ab (P < 0.05). These findings suggest that RINr-ICSA or BSA-Ab may be produced by some similar immune mechanism which is, however, different from ICA, and that they have no direct relation to the clinical course of diabetes.
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