轴手性荧光探针对氨基酸对映选择性识别研究进展

Amino acids serve as essential functional materials in the biomedicine and food sectors， making the pre• cise enantioselective differentiation of chiral amino acids critically important for research.Axially chiral 1， 1'-bi-2naphthol (BINOL) and H 8 BINOL derivatives serve as superior platforms for constructing chiral fluorescent probes， owing to their C2-symmetric rigid skeletons， facile derivatization and outstanding fluorescence properties.This paper reviews the research advances of axially chiral fluorescent probes based on BINOL and H 8 BINOL for enantioselective recognition of amino acids from 2016 to 2026.It categorizes and sorts sensing systems fabricated via diverse modifica• tion strategies targeting typical chiral amino acids including lysine， cysteine， phenylalanine and tryptophan.Empha• sis is placed on molecular synthesis methods， along with optical recognition mechanisms covering PET， ICT， ESIPT and AIE， as well as chiral discrimination modes involving hydrogen bonding， metal coordination and steric match• ing.Existing probes can realize quantitative detection of amino acid enantiomers by means of fluorescence intensity shifts， emission wavelength variations and circular dichroism spectroscopy， and some are applicable to in-situ imag• ing in food matrices and living cells.Nevertheless， several limitations remain， such as poor water solubility， insuffi• 文章编号： 1000-7032(XXXX)XX-0001-16