医学
高强度
腔隙性中风
优势比
磁共振成像
内科学
白质
疾病
痴呆
心脏病学
病理
生物标志物
冲程(发动机)
放射科
缺血性中风
缺血
生物化学
化学
工程类
机械工程
作者
Yi Qu,Cheng Tan,Xue‐Ning Shen,Hongqi Li,Mei Cui,Lan Tan,Qiang Dong,Jin‐Tai Yu
出处
期刊:Stroke
[Ovid Technologies (Wolters Kluwer)]
日期:2021-03-01
卷期号:52 (3): 896-904
被引量:32
标识
DOI:10.1161/strokeaha.120.030302
摘要
Background and Purpose: Neurofilament light chain (NfL) is a promising predictive biomarker of active axonal injury and neuronal degeneration diseases. We aimed to evaluate if an increase in plasma NfL levels could play a monitoring role in the progression of cerebral small vessel disease (CSVD) among the nondemented elders, which are highly prevalent in elderly individuals and associated with an increased risk of stroke and dementia. Methods: The study included 496 nondemented participants from the Alzheimer disease neuroimaging initiative database. All participants underwent plasma NfL measurements and 3.0-Tesla magnetic resonance imaging of the brain; 387 (78.0%) underwent longitudinal measurements. The number of cerebral microbleeds, lacunar infarcts, and volumetric white matter hyperintensities, as well as Fazekas scores, were measured. Cross-sectional and longitudinal associations between CSVD burden and NfL levels were evaluated using multivariable-adjusted models. Results: Plasma NfL was higher in the moderate-severe CSVD burden group (45.2±16.0 pg/mL) than in the nonburden group (34.3±15.1 pg/mL; odds ratio [OR]=1.71 [95% CI, 1.24–2.35]) at baseline. NfL was positively associated with the presence of cerebral microbleeds (OR=1.29 [95% CI, 1.01–1.64]), lacunar infarcts (OR=1.43 [95% CI, 1.06–1.93]), and moderate-severe white matter hyperintensities (OR=1.67 [95% CI, 1.24–2.25]). Longitudinally, a higher change rate of NfL could predict more progression of CSVD burden (OR=1.38 [95% CI, 1.08–1.76]), white matter hyperintensities (OR=1.41 [95% CI, 1.10–1.79]), and lacunar infarcts (OR=1.99 [95% CI, 1.42–2.77]). Conclusions: Plasma NfL level is a valuable noninvasive biomarker that supplements magnetic resonance imaging scans and possibly reflects the severity of CSVD burden. Furthermore, high plasma NfL levels tend to represent an increased CSVD risk, and dynamic increases in NfL levels might predict a greater progression of CSVD.
科研通智能强力驱动
Strongly Powered by AbleSci AI