JAK–STAT pathway targeting for the treatment of inflammatory bowel disease

医学 炎症性肠病 斯达 JAK-STAT信号通路 炎症性肠病 克罗恩病 疾病 癌症研究 免疫学 车站3 内科学 胃肠病学 信号转导 生物 受体 遗传学 酪氨酸激酶
作者
Azucena Salas,Cristian Hernández-Rocha,Marjolijn Duijvestein,William A. Faubion,Dermot McGovern,Séverine Vermeire,Stefania Vetrano,Niels Vande Casteele
出处
期刊:Nature Reviews Gastroenterology & Hepatology [Nature Portfolio]
卷期号:17 (6): 323-337 被引量:483
标识
DOI:10.1038/s41575-020-0273-0
摘要

Cytokines are involved in intestinal homeostasis and pathological processes associated with inflammatory bowel disease (IBD). The biological effects of cytokines, including several involved in the pathology of Crohn’s disease and ulcerative colitis, occur as a result of receptor-mediated signalling through the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) DNA-binding families of proteins. Although therapies targeting cytokines have revolutionized IBD therapy, they have historically targeted individual cytokines, and an unmet medical need exists for patients who do not respond to or lose response to these treatments. Several small-molecule inhibitors of JAKs that have the potential to affect multiple pro-inflammatory cytokine-dependent pathways are in clinical development for the treatment of IBD, with one agent, tofacitinib, already approved for ulcerative colitis and several other agents with demonstrated efficacy in early phase trials. This Review describes the current understanding of JAK–STAT signalling in intestinal homeostasis and disease and the rationale for targeting this pathway as a treatment for IBD. The available evidence for the efficacy, safety and pharmacokinetics of JAK inhibitors in IBD as well as the potential approaches to optimize treatment with these agents, such as localized delivery or combination therapy, are also discussed. The biological effects of cytokines in intestinal homeostasis and disease occur as a result of JAK–STAT signalling. This Review describes the current understanding of JAK–STAT signalling in intestinal homeostasis and inflammatory bowel disease as well as the rationale for therapeutically targeting this pathway.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI5应助tian采纳,获得10
1秒前
1秒前
1秒前
bkagyin应助陌路采纳,获得10
2秒前
jun发布了新的文献求助10
2秒前
herdwind完成签到,获得积分10
2秒前
十二月完成签到,获得积分10
3秒前
能干涵瑶发布了新的文献求助10
3秒前
Z趋势完成签到,获得积分10
3秒前
ding应助看风景悠然在路采纳,获得10
4秒前
李健的小迷弟应助zzy采纳,获得10
5秒前
盐植物完成签到,获得积分10
5秒前
淡淡酬海完成签到,获得积分20
6秒前
three发布了新的文献求助30
6秒前
脑洞疼应助罗永昊采纳,获得10
6秒前
搜集达人应助gaoyi12356采纳,获得10
6秒前
共享精神应助jackie采纳,获得10
7秒前
tunerling完成签到,获得积分10
7秒前
zomozo发布了新的文献求助10
8秒前
藜藜藜在乎你完成签到 ,获得积分10
8秒前
9秒前
滴滴滴完成签到,获得积分20
9秒前
11秒前
GBRUCE完成签到,获得积分10
11秒前
斯文败类应助KM比比采纳,获得10
11秒前
12秒前
jackie完成签到,获得积分10
12秒前
13秒前
冷静新烟发布了新的文献求助10
13秒前
英俊的铭应助生动的踏歌采纳,获得30
13秒前
14秒前
14秒前
15秒前
15秒前
最蠢的讨厌鬼完成签到,获得积分10
16秒前
量子星尘发布了新的文献求助10
16秒前
酷波er应助JohnLemon采纳,获得10
16秒前
神棍喜来乐完成签到,获得积分10
16秒前
淡淡智宸发布了新的文献求助10
18秒前
Lucas应助怪咖采纳,获得10
18秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 1000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3978415
求助须知:如何正确求助?哪些是违规求助? 3522416
关于积分的说明 11213317
捐赠科研通 3259798
什么是DOI,文献DOI怎么找? 1799678
邀请新用户注册赠送积分活动 878563
科研通“疑难数据库(出版商)”最低求助积分说明 806987