生物
红细胞生成
转录组
高原(数学)
缺氧(环境)
造血
信使核糖核酸
基因表达
基因
分子生物学
磷蛋白
基因表达谱
细胞生物学
免疫学
男科
遗传学
内科学
贫血
干细胞
氧气
数学分析
有机化学
化学
医学
数学
作者
Jun Xiao,Xiaowei Li,Fan Xiu,Fuhua Fan,Huifen Lei,Cuiying Li
标识
DOI:10.1089/dna.2019.5004
摘要
The Qing-Tibet Plateau is characterized by low oxygen pressure, which is an important biomedical and ecological stressor. However, the variation in gene expression during periods of stay on the plateau has not been well studied. We recruited eight volunteers to stay on the plateau for 3, 7, and 30 days. Human Clariom D arrays were used to measure transcriptome changes in the mRNA expression profiles in these volunteers' blood. Analysis of variance (ANOVA) indicated that 699 genes were significantly differentially expressed in response to entering the plateau during hypoxic exposure. The genes with changes in transcript abundance were involved in the terms phosphoprotein, acetylation, protein binding, and protein transport. Furthermore, numerous genes involved in hematopoietic functions, including erythropoiesis and immunoregulation, were differentially expressed in response to hypoxia. This phenomenon may be one of reasons why the majority of people entering the plateau do not have excessive erythrocyte proliferation and are susceptible to infection.
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