化学
电泳剂
立体专一性
异构化
手性(物理)
轴手性
西格玛反应
亲电取代
立体化学
艾伦
计算化学
组合化学
催化作用
对映选择合成
有机化学
物理
量子力学
手征对称破缺
Nambu–Jona Lasinio模型
夸克
标识
DOI:10.2174/1385272823666191121122011
摘要
Allenes represent an extremely important class of organic molecules, which, as a result of their twisted orthogonal π-systems can possess axial chirality. A wide array of methods for allene synthesis have been reported, such as the substitution of propargylic electrophiles, isomerization of alkynes and sigmatropic rearrangement. An alternative approach for the synthesis of allenes is 1,2-elimination of an appropriately substituted precursor. This mini-review highlights recent examples of 1,2-elimination processes, which target allenes including both polar and radical processes. The main focus is upon how control over the stereospecificity (e.g. syn- or anti-) of the 1,2-elimination process can enable the synthesis of enantioenriched axially chiral allenes. Recent developments in this field are presented including both enantiospecific and catalytic asymmetric methods.
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