医学                        
                
                                
                        
                            液体活检                        
                
                                
                        
                            甲基化                        
                
                                
                        
                            DNA甲基化                        
                
                                
                        
                            癌症检测                        
                
                                
                        
                            癌症                        
                
                                
                        
                            肿瘤科                        
                
                                
                        
                            内科学                        
                
                                
                        
                            活检                        
                
                                
                        
                            癌症研究                        
                
                                
                        
                            循环肿瘤DNA                        
                
                                
                        
                            基因                        
                
                                
                        
                            遗传学                        
                
                                
                        
                            生物                        
                
                        
                    
            作者
            
                Wenyuan Li,Xianghong Jasmine Zhou            
         
                    
        
    
            
            标识
            
                                    DOI:10.1038/s41571-020-0420-0
                                    
                                
                                 
         
        
                
            摘要
            
            Measuring the methylation status of cell-free DNA (cfDNA) in plasma holds great potential for the early, noninvasive detection of cancer. Two recent papers published in Nature Medicine showcase the successful application of cfDNA methylation-based cancer detection to two highly challenging scenarios.
         
            
 
                 
                
                    
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