纳米工程
纳米医学
微泡
适体
纳米技术
药物输送
靶向给药
仿生材料
计算生物学
材料科学
生物
纳米颗粒
小RNA
分子生物学
生物化学
基因
作者
Phuong Ha Lien Tran,Dongxi Xiang,Thao T.D. Tran,Yin Wang,Yumei Zhang,Lingxue Kong,Kuisheng Chen,Menghong Sun,Yong Li,Yingchun Hou,Y. Zhu,Wei Duan
标识
DOI:10.1002/adma.201904040
摘要
Abstract Targeted exosomal delivery systems for precision nanomedicine attract wide interest across areas of molecular cell biology, pharmaceutical sciences, and nanoengineering. Exosomes are naturally derived 50–150 nm nanovesicles that play important roles in cell‐to‐cell and/or cell‐to‐tissue communications and cross‐species communication. Exosomes are also a promising class of novel drug delivery vehicles owing to their ability to shield their payload from chemical and enzymatic degradations as well as to evade recognition by and subsequent removal by the immune system. Combined with a new class of affinity ligands known as aptamers or chemical antibodies, molecularly targeted exosomes are poised to become the next generation of smartly engineered nanovesicles for precision medicine. Here, recent advances in targeted exosomal delivery systems engineered by aptamer for future strategies to promote human health using this class of human‐derived nanovesicles are summarized.
科研通智能强力驱动
Strongly Powered by AbleSci AI