Innate immune responses against viral pathogens in Macrobrachium

Some members of genus Macrobrachium are important economically prawns and valuable objects for studying the innate immune defense mechanism of crustaceans. Studies have focused on immune responses against bacterial and fungal infections and have expanded to include antiviral immunity over the past two decades. Similar to all living organisms, prawns are exposed to viruses, including white spot syndrome virus, Macrobrachium rosenbergii nodavirus, and Decapod iridescent virus 1 and develop effective defense mechanisms. Here, we review current understanding of the antiviral host defense in two species of Macrobrachium. The main antiviral defense of Macrobrachium is the activation of intracellular signaling cascades, leading to the activation of cellular responses (apoptosis) and humoral responses (immune-related signaling pathways, antimicrobial and antiviral peptides, lectins, and prophenoloxidase-activating system).