小脑
非线性光学
离体
化学
生物医学工程
纳米技术
生物物理学
非线性系统
材料科学
医学
生物化学
生物
体外
物理
基因
泛素连接酶
量子力学
泛素
作者
Chang Woo Park,Seungje Jeon,Seong‐Hoon Kwon,Jun‐Hyung Jung,Jung Eun Seol,Chul‐Seung Park,Steve K. Cho,Do‐Kyeong Ko
标识
DOI:10.1002/jbio.202200139
摘要
By utilizing a multimodal nonlinear optical system that combines coherent anti-Stokes Raman scattering and second harmonic generation to investigate biological characteristics of dermal tissues ex vivo, we demonstrate the potential feasibility of using this optical approach as a powerful new investigative tool for future biomedical research. For this study, our optical system was utilized for the first time to analyze lipid and collagen profiles in cereblon knockout (KO) mouse skin, and we were able to discover significant alterations in the number of carbon-carbon double bonds (wild-type vs. cereblon KO; NCC : 0.75 vs. 0.85) of skin fatty acids in triacylglycerides as well as changes in dermal collagen fibers (25% reduction in cereblon KO). By adopting our optical system to biological studies, we provide researchers with another diagnostic approach to validate their experimental results, which will significantly advance the state of biomedical research.
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