A coiled coil-based pre-targeting drug delivery system for precise treatment of breast cancer

Given the heterogeneous tumor environment and individual differences, separating the "targeting" and "killing" steps enables targeting molecules to bind to different antigens, followed by the application of the Zip1-drug complex without requiring antibody engineering. Our study highlights the potential of this pre-targeting system to efficiently deliver drugs, offering a promising strategy to address challenges faced by ADCs, such as poor tissue penetration, low accumulation, and "on-target, off-tumor" toxicity.