入侵足纲
基质金属蛋白酶
生物
头颈部鳞状细胞癌
癌症研究
细胞外基质
金属蛋白酶
基质金属蛋白酶9
头颈部
基底细胞
头颈部癌
细胞生物学
病理
癌症
转移
医学
遗传学
外科
作者
Levi Arnold,Marrion Yap,Nathan Farrokhian,Laura Jackson,Michael J. Barry,Thuc Ly,Pachiappan Arjunan,Angela Kaczorowski-Worthley,Carter Tews,Avisha Pandey,Austin Morrison,Michael P. Washburn,David Standing,Juan Povedano Gomez,Nanda Kumar Yellapu,David R. Johnson,Linheng Li,Shahid Umar,Shrikant Anant,Sufi M. Thomas
标识
DOI:10.1186/s12943-025-02264-3
摘要
This work unveils a novel function of DCLK1 in regulating KIF16B and RAB40B to traffic matrix degrading MMP9 cargo to the distal end of the invadopodia facilitating HNSCC invasion.
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