衰老
细胞生物学
钥匙(锁)
细胞衰老
细胞
细胞生长
生物
表型
生物化学
基因
生态学
作者
Yi Luan,Xiaofan Zhu,Yanna Jiao,Hui Liu,Zijian Huang,Junchen Pei,Yawei Xu,Yang Yang,Kaidi Ren
标识
DOI:10.1038/s41420-023-01792-5
摘要
Abstract Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age, leading to continuous heart failure, even in people without a prior history of heart disease. To address this issue and improve cardiac cell function, it is crucial to investigate the molecular mechanisms underlying cardiac senescence. This review summarizes the main mechanisms and key proteins involved in cardiac cell senescence. This review further discusses the molecular modulators of cellular senescence in aging hearts. Furthermore, the discussion will encompass comprehensive descriptions of the key drugs, modes of action and potential targets for intervention in cardiac senescence. By offering a fresh perspective and comprehensive insights into the molecular mechanisms of cardiac senescence, this review seeks to provide a fresh perspective and important theoretical foundations for the development of drugs targeting this condition.
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