信号(编程语言)
化学
纳米技术
材料科学
计算机科学
程序设计语言
作者
R. Zhang,Qianyan Zhang,Yonggang Jia,Shengxue Yu,Xinggang Yang,Xiaojun Luo,Ying He
标识
DOI:10.1016/j.foodchem.2024.138717
摘要
Chloramphenicol (CAP) residue in food can cause great harm to human health, it is important to develop a rapid and sensitive method to detect CAP. Here, molecularly imprinted polymer (MIP) was combined with metal-organic frameworks@Au (MOFs@Au) collaborative construction surface-enhanced Raman spectroscopy (SERS) based aptasensor for CAP ultrasensitive detection. MOFs@Au first carried the Raman signal molecule toluidine blue (TB) and aptamer to form MOFs@Au@TB@Apt. In addition, rMIP (CAP was removed) was dropped onto the uniform three-dimensional (3D) SERS substrate SiO2@AuAg to form SiO2@AuAg@rMIP. In the presence of target CAP, it could be specifically captured with rMIP by covalent interaction and was recognised by the aptamer. During this time, SiO2@AuAg@rMIP@CAP could selectively connect MOFs@Au@TB@Apt to realise synergistic enhance the Raman signal. Based on this principle, the proposed SERS aptasensor exhibits excellent sensitivity with a detection limit of 7.59×10−13 M for CAP, providing a new strategy for trace detection in food.
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