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The potential role of systemic inflammatory markers in predicting recurrence in early-stage cervical cancer

医学 内科学 中性粒细胞与淋巴细胞比率 胃肠病学 阶段(地层学) 全身炎症 癌症 单中心 炎症 淋巴细胞 外科 肿瘤科 生物 古生物学
作者
Matteo Bruno,Nicolò Bizzarri,Elena Teodorico,Camilla Certelli,Valerio Gallotta,Luigi Pedone Anchora,Anna Fagotti,Francesco Fanfani,Giovanni Scambia,Luigi Pedone Anchora
出处
期刊:Ejso [Elsevier]
卷期号:50 (1): 107311-107311
标识
DOI:10.1016/j.ejso.2023.107311
摘要

The influence of systemic inflammatory markers on early-stage cervical cancer (ECC) patients is contradictory. No previous study analyzed whether these markers may be suggestive of recurrence. The aim of this study was to assess whether the inflammatory markers level of patients with recurrence during surveillance was different from those of patients without recurrence representing a risk factor for recurrence.Retrospective, single-center, observational study. Patients with 2009 FIGO EEC surgically treated between 2012 and 2019 were included. Baseline inflammatory markers were evaluated on the results of the complete blood count (CBC) and coagulation tests. Inflammatory markers of relapsed patients were evaluated on the last CBC performed before the relapse diagnosis. Inflammatory markers of patients with no recurrence were evaluated on the available CBC taken at the same median follow-up time as the one from relapsed patients.174 patients were included. Baseline Systemic immune inflammation index (SII) > 663 and Systemic inflammation response index (SIRI) > 0.98 were associated with significant risk of recurrence. SII>663 and Neutrophil to lymphocyte ratio (NLR) > 2.41 were associated with increased risk of death. Significant changes between relapsed (n = 23) and non-relapsed (n = 151) patients in median values of SII (615 versus 490, p-value = 0.001), SIRI (0.74 versus 1.05, p-value = 0.005), NRL (2.95 versus 2.15, p-value = 0.0035), and MLR (0.26 versus 0.22 p-value = 0.020), showed that different levels of inflammatory markers could help identifying recurrent disease during surveillance.Baseline SII>663 and SIRI>0.98 were associated with increased risk of recurrence. Higher median values of SII, SIRI, NLR and MLR in relapsed patients highlight their potential association with recurrence.
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