去整合素
磷脂酰丝氨酸
神经氨酸酶
细胞生物学
内皮干细胞
胰岛素
外化
胰岛素受体
信号转导
内科学
基质金属蛋白酶
内分泌学
生物
化学
金属蛋白酶
胰岛素抵抗
医学
酶
生物化学
磷脂
体外
膜
心理学
精神分析
作者
Larissa Ferreira‐Santos,Francisco I. Ramirez‐Perez,Christopher Foote,Marc Augenreich,N. J. McMillan,Megan E. Williams,Juan D. Gonzalez-Vallejo,Gavin Power,Andrew A. Wheeler,Camila Manrique‐Acevedo,Luis A. Martinez‐Lemus,Jaume Padilla
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2024-01-01
卷期号:326 (1): H270-H277
标识
DOI:10.1152/ajpheart.00638.2023
摘要
This work provides the first evidence that neuraminidase, an enzyme increased in the circulation of men and women with type 2 diabetes (T2D), promotes anoctamin-6 (ANO6)-dependent externalization of phosphatidylserine in endothelial cells, which in turn leads to activation of a disintegrin and metalloproteinase-17 (ADAM17) and consequent shedding of the insulin receptor-α from the cell surface. Hence, this work supports that consideration should be given to the neuraminidase-ANO6-ADAM17 axis as a novel potential target for restoring endothelial insulin sensitivity in T2D.
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