串扰
肿瘤微环境
免疫系统
免疫学
生物
树突状细胞
医学
癌症研究
工程类
电子工程
作者
Leilei Yang,Songya Li,L. Chen,Yi Zhang
标识
DOI:10.20892/j.issn.2095-3941.2023.0241
摘要
Plasmacytoid dendritic cells (pDCs) are a pioneer cell type that produces type I interferon (IFN-I) and promotes antiviral immune responses. However, they are tolerogenic and, when recruited to the tumor microenvironment (TME), play complex roles that have long been a research focus. The interactions between pDCs and other components of the TME, whether direct or indirect, can either promote or hinder tumor development; consequently, pDCs are an intriguing target for therapeutic intervention. This review provides a comprehensive overview of pDC crosstalk in the TME, including crosstalk with various cell types, biochemical factors, and microorganisms. An in-depth understanding of pDC crosstalk in TME should facilitate the development of novel pDC-based therapeutic methods.
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