环丁烷
化学
对映选择合成
环丁烷
催化作用
组合化学
环加成
有机化学
戒指(化学)
作者
Matthew J. Genzink,Matthew D. Rossler,Herman Recendiz,Tehshik P. Yoon
摘要
Pseudodimeric cyclobutanes constitute a large class of natural products that could, in principle, be efficiently synthesized via [2+2] photocycloadditions. However, the difficulty in developing chemo-, regio-, diastereo-, and enantioselective cycloadditions has limited their use in asymmetric syntheses. Herein, we show that chiral acid catalysts promote highly selective visible-light photocycloadditions, the products of which can be quickly transformed into truxinate natural products. This general approach has enabled the synthesis of both dimeric and pseudodimeric cyclobutane natural products with excellent enantioselectivity.
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