淋巴细胞性脉络膜脑膜炎
淋巴毒素
CD11c公司
生物
免疫学
生发中心
脾脏
边缘地带
B细胞
免疫系统
表型
抗体
CD8型
生物化学
基因
作者
Wenzhi Song,Gina M. Sanchez,Daniel P. Mayer,Holly N. Blackburn,Irene Chernova,Richard A. Flavell,Jason S. Weinstein,Joe Craft
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2023-05-05
卷期号:210 (12): 1861-1865
标识
DOI:10.4049/jimmunol.2300027
摘要
Tbet+CD11c+ B cells, also known as age-associated B cells (ABCs), are pivotal contributors to humoral immunity following infection and in autoimmunity, yet their in vivo generation is incompletely understood. We used a mouse model of systemic acute lymphocytic choriomeningitis virus infection to examine the developmental requirements of ABCs that emerged in the spleen and liver. IL-21 signaling through STAT3 was indispensable for ABC development. In contrast, IFN-γ signaling through STAT1 was required for B cell activation and proliferation. Mice that underwent splenectomy or were deficient in lymphotoxin α generated hepatic ABCs despite the lack of secondary lymphoid organ contributions, suggesting that the liver supported de novo generation of these cells separately from their development in lymphoid organs. Thus, IFN-γ and IL-21 signaling have distinct, stage-specific roles in ABC differentiation, while the tissue microenvironment provides additional cues necessary for their development.
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