Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians

医学 神经科学 内科学 心理学
作者
Estrella Gómez‐Tortosa,Pablo Agüero,Alicia Ruiz-González,Sonia Wagner,Raquel Téllez,Ignacio Mahíllo,Andrea Ruiz-Calvo,María José Sainz,Anna Nyström,Lucía Cremades‐Jimeno,Teodoro del Ser,Pascual Sánchez-Juan
出处
期刊:Aging and Disease [Buck Institute for Research on Aging]
标识
DOI:10.14336/ad.2024.1260
摘要

Plasma biomarkers represent promising tools for the screening and diagnosis of patients with neurodegenerative conditions. However, it is crucial to account for the effects of aging on biomarker profiles, especially in the oldest segments of the population. Additionally, biomarkers in this sample can offer in vivo insights into the physiological mechanisms underlying brain aging while concomitantly supporting cognitive preservation. In this study we analyzed plasma Alzheimer's disease (AD) core biomarkers, neurofilament light chain (NfL), and glial fibrillary acid protein (GFAP) using the Single Molecule Array (SIMOA) platform in 75 cognitively preserved nonagenarians, and compared with baseline samples of 153 volunteers who were cognitively unimpaired (CU) during six years (classified in ≤ 70, and 71 to 85 years of age), and with 108 AD patients. Nonagenarians almost lack the APOEε4 allele, and had significantly higher Aß40, Aß42, p-tau181, NfL, and GFAP, along with a significantly lower Aß42/40 ratio (P&;lt0.001) compared with the two CU groups. NfL and GFAP tripled concentrations in nonagenarians. No differences were noted in any plasma biomarker between the younger and older CU groups. Biomarkers correlated strongly with age only when analyzing together CU controls and nonagenarians. Compared with AD cases, nonagenarians showed lower p-tau181 (P=0.001), higher total tau (P=0.02), and much higher Aß40, Aß42 and NfL levels (P&;lt0.001). The levels of GFAP in nonagenarians were similar to those observed in AD patients. In conclusion, cognitively preserved nonagenarians do not develop the AD biomarker signature and exhibit higher levels of Aß42. However, their threefold increase in NfL and GFAP supports their aging brains are somehow resilient to neurodegeneration. These data support caution in the prognosis of clinical dementia based on NfL and GFAP values. Overall, plasma biomarkers in CU individuals remained quite stable till the eighties.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
jw完成签到 ,获得积分10
刚刚
拼搏的问玉完成签到,获得积分10
1秒前
休亮发布了新的文献求助10
2秒前
范德萨范德萨完成签到,获得积分10
2秒前
高高的幻莲完成签到,获得积分10
4秒前
休亮完成签到,获得积分10
6秒前
香蕉觅云应助ESLG采纳,获得10
6秒前
aafrr完成签到 ,获得积分10
6秒前
wangpeng完成签到 ,获得积分10
6秒前
迅速的萧完成签到 ,获得积分10
6秒前
6秒前
搞学术的小傻子完成签到,获得积分10
7秒前
苹果白凝完成签到,获得积分20
7秒前
科研通AI5应助sisi采纳,获得10
7秒前
flash完成签到,获得积分10
8秒前
8秒前
陶世立完成签到 ,获得积分10
8秒前
学分完成签到 ,获得积分10
10秒前
yulian完成签到,获得积分10
11秒前
jjjwln完成签到,获得积分10
11秒前
飞兰完成签到,获得积分10
11秒前
SaSa发布了新的文献求助10
11秒前
会撒娇的天抒完成签到,获得积分10
12秒前
苹果白凝发布了新的文献求助30
12秒前
棠棠完成签到 ,获得积分10
12秒前
优雅盼海发布了新的文献求助10
12秒前
12秒前
Ava应助三眼乌鸦采纳,获得10
13秒前
鲤鱼问雁完成签到,获得积分10
13秒前
务实雁梅完成签到,获得积分10
14秒前
顾矜应助LZR采纳,获得10
14秒前
14秒前
weadu完成签到,获得积分10
15秒前
Li应助板凳儿cc采纳,获得10
16秒前
rym完成签到 ,获得积分10
16秒前
17秒前
超帅鸣凤完成签到,获得积分10
17秒前
ESLG发布了新的文献求助10
17秒前
闪闪路人完成签到,获得积分10
17秒前
18秒前
高分求助中
Technologies supporting mass customization of apparel: A pilot project 600
Izeltabart tapatansine - AdisInsight 500
Chinesen in Europa – Europäer in China: Journalisten, Spione, Studenten 500
Arthur Ewert: A Life for the Comintern 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi // Kurt Werner Radtke 500
Two Years in Peking 1965-1966: Book 1: Living and Teaching in Mao's China // Reginald Hunt 500
Epigenetic Drug Discovery 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3815945
求助须知:如何正确求助?哪些是违规求助? 3359450
关于积分的说明 10402728
捐赠科研通 3077293
什么是DOI,文献DOI怎么找? 1690285
邀请新用户注册赠送积分活动 813693
科研通“疑难数据库(出版商)”最低求助积分说明 767743