Glycosylation using diethyl phosphite donor activated by edible polyphenol ellagic acid

The glycosylation reactions of diethyl phosphite donor with various alcohol acceptors were examined using ellagic acid, an edible polyphenol, as an activator. These reactions proceeded smoothly under mild conditions to afford the corresponding glycosides in high yields. Notably, this method represents the first use of ellagic acid for the activation of phosphite donor and was applicable to a broad range of alcohol acceptors.