Immunoregulatory electrospinning fiber mediates Macrophage energy metabolism reprogramming to promote burn wound healing

experiment showed that PEKUU electrospinning fiber could accelerate epithelialization, collagen remodeling and healing of deep second-degree burn wounds of mice. Finally, proteomics was applied to reveal the underlying mechanism of AKG-mediated metabolic reprogramming, including the coordinated suppression of the glycolytic-NF-κB axes and the potentiation of the OXPHOS and fatty acid oxidation pathways. The dual regulation reshaped macrophage energetics and established a pro-regenerative niche. Overall, PEKUU electrospinning dressing could modulate macrophage polarization state by reprogramming energy metabolism mode, providing a new therapeutic strategy for burn repair.