Alternating Interlayered Piezoelectric Self‐Heterojunction Boosts Sono‐Piezocatalytic Pyroptosis Oncotherapy

-BOS demonstrates efficient reactive oxygen species production and exhibits superior peroxidase and catalase-like activities compared to the conventional piezoelectric nanocatalysts. Consequently, the enhanced radical generation induced the specific cancer-cell pyroptosis via caspase-3 mediated gasdermin E-dependent pathway. Therefore, the engineered interlayer self-heterojunction provides an efficient strategy for the design and engineering of high-performance piezoelectric nanocatalysts.