化学
真菌
电喷雾电离
金黄色葡萄球菌
立体化学
乙醚
质谱法
二维核磁共振波谱
核磁共振波谱
最小抑制浓度
抗菌剂
黑曲霉
抗菌活性
生物活性
质子核磁共振
部分
质谱
电喷雾
IC50型
核磁共振谱数据库
细胞毒性
碳-13核磁共振
电离
生物测定
细胞毒性T细胞
有机化学
作者
Yanchun He,S. Y. Xu,Juan Gao,Juan Liu,Xuefeng Zhou,Yonghong Liu,Xiao‐Yong Zhang,Bin Yang
标识
DOI:10.1002/cbdv.202502248
摘要
Three new phenyl ether derivatives (1-3) and 11 known compounds (4-14) were isolated from the deep-sea-derived fungus Aspergillus sp. SCSIO 41230. The structures of the new compounds were elucidated by analysis of the nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry, and NMR calculations. The bioassays indicated that compound 6 showed weak cytotoxic activity against PC-3 and 22Rv1 cells, and compound 4 exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration value of 4.13 µg/mL.
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