小RNA
生物
抑制器
癌症
Oncomir公司
功能(生物学)
计算生物学
癌症生物标志物
生物标志物
生物信息学
遗传学
基因
作者
Lütfi Tutar,Esen Tutar,Yusuf Tutar
出处
期刊:Current Pharmaceutical Biotechnology
[Bentham Science]
日期:2014-08-31
卷期号:15 (5): 430-437
被引量:77
标识
DOI:10.2174/1389201015666140519095304
摘要
MiRNAs are a family of small, endogenous, and evolutionarily conserved non-coding ribonucleic acids that have been involved in the regulation of several essential, cellular, and functional processes. MicroRNAs are known to play key roles in all types of cancer and function as oncogenes (oncomirs) or tumour-suppressors in up-regulation or down-regulation processes respectively. MiRNAs have potential power to be examined as prognostic and diagnostic biomarkers. Modulating miRNAs, based on two major approaches (miRNA mimics and miRNA antagonists), is used for clinical development of therapeutic miRNAs. This review emphasizes the latest discovery in the field of miRNA research involved in cancer, biomarkers, and therapeutics. Keywords: Biomarkers, cancer, microRNAs, therapeutics.
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