淀粉样前体蛋白
信号转导衔接蛋白
细胞生物学
α分泌酶
血浆蛋白结合
转染
阿尔茨海默病
淀粉样前体蛋白分泌酶
结合位点
神经科学
舱室(船)
生物
化学
生物化学
基因
信号转导
疾病
医学
内科学
地质学
海洋学
作者
Kwok‐Fai Lau,Declan M. McLoughlin,Claire L. Standen,Nicholas G. Irving,Christopher C.J. Miller
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:2000-11-01
卷期号:11 (16): 3607-3610
被引量:41
标识
DOI:10.1097/00001756-200011090-00041
摘要
The Fe65s and X11s are two families of adaptor proteins that bind to the Alzheimer's disease amyloid precursor protein (APP). Although both the X11s and Fe65s bind to similar regions of APP, they have opposing effects on Abeta production and hence may represent novel therapeutic targets. However, there is no evidence that the Fe65s and X11s are present within the same cell type or cell compartment and are thus capable of competing for binding to APP. Here we show that in neurones and transfected cells, APP, Fe65 and X11beta show overlapping subcellular distributions. Furthermore, we demonstrate that Fe65 and X11beta compete for binding to APP.
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