菌丝体
抗生素
生物
色谱法
化学
植物
酵母抽提物
微生物学
生物化学
发酵
作者
Federico Arcamone,Giuseppe Cassinelli,G. Fantini,A. Grein,P. Orezzi,C. Pol,C. Spalla
标识
DOI:10.1002/bit.260110607
摘要
Abstract Streptomyces peucetius var. caesius , obtained from S. peucetius , the daunomycin producing microorganism, by mutagenic treatment, differs from the parent culture by the color of the vegetative and aerial mycelia and by its antibiotic, producing ability. S. peucetius var. caesius accumulates adriamycin in submerged and aerated culture on a medium containing glucose, brewer's yeast, and inorganic, salts both in shake flasks and in stirred fementers. Isolation of the product is performed by solvent extraction, chromatography on buffered cellulose columns, and crystallization as the hydrochloride. The new antitumor agent, adriamycin, is the 14‐hydroxv derivative of daunomyein.
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