The slippage resistance of yarns at the seam in woven fabrics is a very important factor and very strict claims are made with respect to this property. It is necessary to know how the fabric structure influences seam slippage quality before manufacturing a fabric. The purpose of this work was to establish which of the fabric structure parameters influence seam slippage. Our previous work investigated the influence of weave on the seam slippage characteristics of a fabric, and a new weave factor was proposed which best characterises the weave from the thread slippage point of view. It was found that the seam slippage influences not only the weave factor in the slip direction but also in the normal direction. In the paper, by means of the design of experiments, the influence of weave, warp density and weft density on seam slippage was investigated. It was found that the warp density has a very low influence on seam slippage characteristics. Only the weft density and weave influence seam slippage. Key words: woven fabrics weave factor, seam slippage, fabric structure and density.