Development and validation of a risk-of-bias tool for assessing in vitro studies conducted in dentistry: The QUIN

Systematic reviews and meta-analyses have emerged as forerunners of evidence-based dentistry, but assessing the quality of the available research is essential so that it can be applied to clinical practice. While a wide variety of risk-of-bias tools are available, each specifically developed for different study designs, a comprehensive tool exclusively framed to assess the quality of in vitro dental studies is lacking.