伤口愈合
无毛
促炎细胞因子
医学
毛囊
雄激素受体
下调和上调
睾酮(贴片)
炎症
内分泌学
药理学
内科学
癌症研究
免疫学
生物
生物化学
遗传学
前列腺癌
癌症
基因
作者
Gillian S. Ashcroft,Stuart J. Mills
摘要
Impaired wound healing states in the elderly lead to substantial morbidity, mortality, and a cost to the US Health Services of over $9 billion per annum.In addition to intrinsic aging per se causing delayed healing, studies have suggested marked sex-differences in wound repair.We report that castration of male mice results in a striking acceleration of local cutaneous wound healing, and is associated with a reduced inflammatory response and increased hair growth.Using a hairless mouse model, we have demonstrated that testosterone reduction stimulates the healing response not through hair follicle epithelial/mesenchymal cell proliferation, but directly via effects on wound cell populations.We suggest that endogenous testosterone inhibits the cutaneous wound healing response in males and is associated with an enhanced inflammatory response.The mechanisms underlying the observed effects involve a direct upregulation of proinflammatory cytokine expression by macrophages in response to testosterone.Blockade of androgen action systemically, via receptor antagonism, accelerates healing significantly, suggesting a specific target for future therapeutic intervention in impaired wound healing states in elderly males.
科研通智能强力驱动
Strongly Powered by AbleSci AI