Asymmetric total synthesis of buprenorphine and dihydroetorphine

The concise asymmetric total synthesis of buprenorphine and dihydroetorphine has been achieved without the consumption of naturally occurring thebaine. Central to the synthesis is the employment of a thebaine-like intermediate, which is easily available through a bioinspired Pd-catalyzed dearomatization arene coupling reaction to forge the morphinan core.