Inhibitory activity of flavonoids against human sucrase-isomaltase (α-glucosidase) activity in a Caco-2/TC7 cellular model

Flavonoids may be effective inhibitors of SI in Caco-2/TC7 cells when using natural substrates maltose and sucrose. The chemical features that favor the SI inhibition by flavonoids are the presence of –OH groups at C-3, C-3′, C-4′, C-7 and C-8.