双层
透射电子显微镜
小泡
脂质双层
相(物质)
纳米材料
纳米颗粒
化学
化学工程
模型脂质双层
材料科学
纳米技术
膜
化学物理
结晶学
脂质双层相行为
有机化学
生物化学
工程类
作者
Aoon Rizvi,Justin T. Mulvey,Joseph P. Patterson
出处
期刊:Nano Letters
[American Chemical Society]
日期:2021-12-10
卷期号:21 (24): 10325-10332
被引量:16
标识
DOI:10.1021/acs.nanolett.1c03556
摘要
Liquid-phase transmission electron microscopy (LP-TEM) enables the real-time visualization of nanoscale dynamics in solution. This technique has been used to study the formation and transformation mechanisms of organic and inorganic nanomaterials. Here, we study the formation of block-copolymer-supported bilayers using LP-TEM. We observe two formation pathways that involve either liquid droplets or vesicles as intermediates toward supported bilayers. Quantitative image analysis methods are used to characterize vesicle spread rates and show the origin of defect formation in supported bilayers. Our results suggest that bilayer assembly methods that proceed via liquid droplet intermediates should be beneficial for forming pristine supported bilayers. Furthermore, supported bilayers inside the liquid cells may be used to image membrane interactions with proteins and nanoparticles in the future.
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