The aim of the work was to study the structure and dynamics of psychopathological symptoms among HIV-positive and HIV-negative patients with opiate addiction. Material and methods The survey was attended by 820 patients. We studied the parameters of the main psychopathological symptoms using a questionnaire SCL-90-R in the dynamics. The structure of psychopathology in patients with opiate addiction is presented. The changes psychopathological indicators of the state of the examined patients before and after complex rehabilitation, after 1, 3, 6 and 12 months from the start of observation are given. Results The findings suggest the presence of more severe psychopathology HIV-positive patients than HIV-negative patients with opiate addiction. It was found that the quantity indicators SCL-90-R in the examined patients, despite the positive trend at discharge significantly higher than in healthy individuals. Conclusion The results of the study indicate a lack of short-stage therapy to normalize the mental state of opiate addiction and the need to develop an algorithm of a long, corrected with the needs of patients, comprehensive rehabilitation programs.