A highly enantioselective synthesis of ( R )-salmeterol using a chiral auxiliary

A facile strategy for enantioselective synthesis of ( R)-salmeterol is described via a chiral auxiliary starting from 2-bromo-1-(2,2-dimethyl-4 H-1,3-benzodioxin-6-yl)ethanone through four or five steps. The product was obtained in good purity, enantiomeric excess and yield.