TBX1型
生物
转录因子
单倍率不足
基因
遗传学
表观遗传学
激活剂(遗传学)
基因表达调控
发起人
细胞生物学
基因表达
表型
作者
Antonio Baldini,Filomena Gabriella Fulcoli,Elisabeth Anne Illingworth
出处
期刊:Current Topics in Developmental Biology
日期:2017-01-01
卷期号:: 223-243
被引量:52
标识
DOI:10.1016/bs.ctdb.2016.08.002
摘要
Recent data have paved the way to mechanistic studies into the role of Tbx1 during development. Tbx1 is haploinsufficient and is involved in an important genetic disorder. The gene encodes a T-box transcription factor that is expressed from approximately E7.5 in mouse embryos and continues to be expressed in a highly dynamic manner. It is neither a strong transcriptional activator nor a strong repressor, but it regulates a large number of genes through epigenetic modifications. Here, we review recent literature concerning mechanisms of gene regulation by Tbx1 and its role in mammalian development, with a special focus on the cardiac, vascular, and central nervous systems.
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