医学
结直肠癌
观察研究
内科学
肿瘤科
阿司匹林
辅助治疗
佐剂
癌症
生物标志物
生物化学
化学
作者
Ruth E Langley,Peter M. Rothwell
标识
DOI:10.1038/nrclinonc.2012.216
摘要
Patients with colorectal cancer with mutated PIK3CA, identified from two large observational cohorts, had increased cancer-specific and overall survival if they used aspirin regularly after diagnosis compared to non-users. No effect of aspirin was seen in patients with wild-type PIK3CA. Mutated PIK3CA might be a useful biomarker to select patients who would benefit from adjuvant aspirin therapy.
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