Hepatitis B Virus Reactivation after a Single Session of Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma

Letters15 April 2003Hepatitis B Virus Reactivation after a Single Session of Transarterial Chemoembolization in Patients with Hepatocellular CarcinomaGiovan B. Vizzini, MD, Angelo Luca, MD, and Ignazio R. Marino, MDGiovan B. Vizzini, MDIstituto Mediterraneo per i Trapianti e, Terapie ad Alta Specializzazione; 90134 Palermo, Italy (Vizzini, Luca, Marino)University of Pittsburgh Medical Center; Pittsburgh, PA 15213 (Vizzini, Luca, Marino), Angelo Luca, MDIstituto Mediterraneo per i Trapianti e, Terapie ad Alta Specializzazione; 90134 Palermo, Italy (Vizzini, Luca, Marino)University of Pittsburgh Medical Center; Pittsburgh, PA 15213 (Vizzini, Luca, Marino), and Ignazio R. Marino, MDIstituto Mediterraneo per i Trapianti e, Terapie ad Alta Specializzazione; 90134 Palermo, Italy (Vizzini, Luca, Marino)University of Pittsburgh Medical Center; Pittsburgh, PA 15213 (Vizzini, Luca, Marino)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-8-200304150-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Hepatitis B virus (HBV) reactivation is a well-recognized complication in patients with cancer receiving systemic cytotoxic chemotherapy (1) and may cause varying degrees of liver damage. Immunosuppression due to cytotoxic therapy enhances viral replication and infection of the hepatocytes (2). Withdrawal of chemotherapy leads to restoration of immune function, with a consequent potential risk for rapid destruction of infected hepatocytes. Reactivation of HBV has been reported mostly in hepatitis B surface antigen (HBsAg) carriers with lymphoma after systemic chemotherapy or bone marrow transplantation (3). In some cases, HBV reactivation has been severe and has resulted in ...References1. Hoofnagle JH, Dusheiko GM, Schafer DF, Jones EA, Micetich KC, Young RC, . Reactivation of chronic hepatitis B virus infection by cancer chemotherapy. Ann Intern Med. 1982;96:447-9. [PMID: 7065560] LinkGoogle Scholar2. Davis GL, Hoofnagle JH. Reactivation of chronic hepatitis B virus infection [Editorial]. Gastroenterology. 1987;92:2028-31. [PMID: 3569777] CrossrefMedlineGoogle Scholar3. Yeo W, Chan PK, Zhong S, Ho WM, Steinberg JL, Tam JS, . Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors. J Med Virol. 2000;62:299-307. [PMID: 11055239] CrossrefMedlineGoogle Scholar4. Chen PM, Chiou TJ, Fan FS, Liu JM, Hsieh RK, Yen CC, . Fulminant hepatitis is significantly increased in hepatitis B carriers after allogeneic bone marrow transplantation. Transplantation. 1999;67:1425-33. [PMID: 10385080] CrossrefMedlineGoogle Scholar5. Yeo W, Steinberg JL, Tam JS, Chan PK, Leung NW, Lam KC, . Lamivudine in the treatment of hepatitis B virus reactivation during cytotoxic chemotherapy. J Med Virol. 1999;59:263-9. [PMID: 10502254] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Giovan B. Vizzini, MD; Angelo Luca, MD; Ignazio R. Marino, MDAffiliations: Istituto Mediterraneo per i Trapianti e, Terapie ad Alta Specializzazione; 90134 Palermo, Italy (Vizzini, Luca, Marino)University of Pittsburgh Medical Center; Pittsburgh, PA 15213 (Vizzini, Luca, Marino) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatitis B Virus Reactivation Potential Risk Factors in Hepatocellular Carcinoma via Transcatheter Arterial Chemoembolization: A Retrospective ResearchEffects of TACE and preventive antiviral therapy on HBV reactivation and subsequent hepatitis in hepatocellular carcinoma: a meta-analysisChanges of HBV DNA After Chemoembolization for Hepatocellular Carcinoma and the Efficacy of Antiviral TreatmentPostoperative hepatitis B virus reactivation and surgery-induced immunosuppression in patients with hepatitis B-related hepatocellular carcinomaAntiviral therapy decreases viral reactivation in patients with hepatitis B virus-related hepatocellular carcinoma undergoing hepatectomy: a randomized controlled trialEffects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinomaThe Effect of Transcatheter Arterial Chemoembolization on Hepatitis C ViremiaHow does hepatitis B virus infection react to hepatocellular carcinoma treatment?Hepatic and biliary damage after transarterial chemoembolization for malignant hepatic tumors: Incidence, diagnosis, treatment, outcome and mechanismChanges in hepatitis B virus DNA levels and liver function after transcatheter arterial chemoembolization of hepatocellular carcinomaArterial Chemoembolization/Embolization and Early Complications after Hepatocellular Carcinoma Treatment: A Safe Standardized Protocol in Selected Patients with Child Class A and B CirrhosisPostresectional Adjuvant Intraportal Chemotherapy in Patients with Hepatocellular Carcinoma: A Case-Control StudyRisk of Hepatitis B Exacerbation is Low After Transcatheter Arterial Chemoembolization Therapy for Patients with HBV-related Hepatocellular Carcinoma: Report of a Prospective StudyTransarterial chemo-lipiodolization can reactivate hepatitis B virus replication in patients with hepatocellular carcinomaOut of control: hepatitis B reactivation by transarterial treatment of hepatocellular carcinoma 15 April 2003Volume 138, Issue 8Page: 691-692KeywordsAlanine aminotransferaseBilirubinChemotherapyCirrhosisDNAHepatitis B virusHepatocellular carcinomaLiverPatient advocacySerum glutamic oxaloacetic transaminase ePublished: 15 April 2003 Issue Published: 15 April 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. 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