Aesthetic hand rejuvenation and restoration have been relatively overlooked compared with other aesthetic enhancements. Cosmetic dermal fillers provide physicians and patients with a nonsurgical option for restoring volume and a youthful appearance to the aging and damaged hand. This paper presents the clinical experience of patients who received Dermicol-P35 30G (Evolence Breeze; Ortho Dermatologics, Skillman, NJ) injection for rejuvenation and restoration of the hand.