Collagen-Containing Fillers: Alone and in Combination

Collagen, the major structural component of the dermis and the most abundant protein found in humans, is responsible for imparting strength and support to human skin. Loss of collagen with aging and sun exposure leads to skin fragility. In addition, it may play a role in facial flushing in patients who have rosacea and severe photodamage. It is believed that loss of the collagen support surrounding the blood vessels allows the vessels to remain dilated, giving the skin a flushed appearance. Preventing the loss of collagen is the purpose of many skin care topical products and oral supplements.