大麻素
生物
大麻
基因
大麻
拷贝数变化
适应(眼睛)
遗传学
基因复制
遗传变异
进化生物学
计算生物学
基因组
植物
神经科学
医学
精神科
受体
作者
Daniela Vergara,Ezra L. Huscher,Kyle G. Keepers,Robert M. Givens,Christian G. Cizek,Anthony R. Torres,Reggie Gaudino,Nolan C. Kane
摘要
Abstract Gene copy number variation is known to be important in nearly every species where it has been examined. Alterations in gene copy number may provide a fast way of acquiring diversity, allowing rapid adaptation under strong selective pressures, and may also be a key component of standing genetic variation within species. Cannabis sativa plants produce a distinguishing set of secondary metabolites, the cannabinoids, many having medicinal utility. Two major cannabinoids -- THCA and CBDA -- are products of a three-step biochemical pathway. Using genomic data for 69 Cannabis cultivars from diverse lineages within the species, we found that genes encoding the synthases in this pathway vary in copy number, and that the cannabinoid paralogs may be differentially expressed. We also found that copy number partially explains variation in cannabinoid content levels among Cannabis plants.
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