天麻
Phoma公司
真菌
发酵
立体化学
次生代谢物
生物
内生真菌在植物防御中的应用
抗菌剂
植物
代谢物
化学
内生菌
生物化学
微生物学
替代医学
中医药
病理
基因
医学
作者
Hongtao Li,Hao Zhou,Rong‐Ting Duan,Lin-Huan Tang,Xue‐Qiong Yang,Ya‐Bin Yang,Zhong‐Tao Ding
标识
DOI:10.1021/acs.jnatprod.8b00685
摘要
Co-culturing the endophytic fungus Phoma sp. YUD17001 from Gastrodia elata with Armillaria sp. in liquid nutrient medium resulted in the production of five new secondary metabolites, including two phenolic compounds, phexandiols A and B (1 and 2), three aliphatic ester derivatives, phomesters A-C (3-5), and a known fatty acid (6). The structures and absolute configurations of these compounds were elucidated by the interpretation of data from detailed spectroscopic analysis, Mosher's method, and electronic circular dichroism spectra, together with consideration of the biogenetic origins. None of the five new compounds were detected in single-strain cultures under identical fermentation conditions. The results of this work indicated that the production of 1-5 involved a complicated interaction process. None of the new compounds possessed significant cytotoxicity or antimicrobial activities.
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