Drainage and detoxication functions of lymphatic system at regional level are discussed. Lymphodetoxication is regarded as a unity of biophysical, biochemical and immune actions upon the lymph in lymphoid structures of an anatomical region. Regional lymphatic drainage is considered as a three-component mechanism, that includes interstitial pathways of non-vascular microcirculation, regional lymphatic vessels and lymph nodes. As a whole, this construction represents a lymphatic region, that includes, besides the pathways of vascular and non-vascular lymph circulation, other lymphoid structures, which are present in this region (individual cells, constant and temporary aggregations of lymphoid tissue).