Clinical Study on Female Patients with Bladder Irritability

We conducted a clinical study on the relationship between bacteriuria, pyuria and subjective symptoms in 1353 female patients without any underlying disease but complaining of bladder irritability.The results were as follows:1) Two-thirds of these patients met the standard criteria of typical acute cystitis by the Japanese UTI committee, while those remaining were judged to have atypical acute cystitis.2) The symptom of pain on urination, one of the requirements to meet the standard criteria, was found in fifty eight percent of those with atypical acute cystitis.3) Sixty one percent of the patients with atypical acute cystitis had pyuria of more than 10 WBCs/hpf and fifty one percent bacteriuria of more than 104 cfu/ml.4) The analysis of the correlation between the degree of bacteriuria, the degree of pyuria and the severity of subjective symptoms revealed a stronger correlation between bacteriuria and pyuria, and pyuria and subjective symptoms, followed by bacteriuria and subjective symptoms, in this order.When taking it into consideration that bacteria multiply in bladder urine, which elicits a local defense response representing the appearance of pyuria, resulting finally in subjective symptoms, the results described above are valid.