Alcohol gasoline as vehicle fuel is prepared by fuel alcohol and gasoline, its octane number is frequently determined during preparation. The model of pre -determining octane number of alcohol gasoline is established on the basis of octane numbers obtained by the standard method, and its precise and repeatability are validated. The result shows that the model can not only replace the standard method (GB/T 5487 and GB/T 503), but also remarkably save analysis time and expenses and have obvious economic benefits.