Objective To evaluate the efficacy of Thalidomide+MP in the anaemia of multiple myeloma. Mothods Case-control study.One group received Thalidomide+MP, Thalidomide 25mg/d,p.o., d1~21.MP(Mel.10mg/㎡·d,p.o.,four days,Prep.2mg/kg·d,p.o.,four days ,for four weeks).the other group received MP,the method is alike.Result The increment of Thalidomide+MP was greater than in the control group.Conclusion Thalidomide+MP is more effective for the anaemia of multiple myeloma.