Research of the Glypican-3 Expression in Hepatocelluar Carcinoma and its Clinicopathogical Relevance

Objective To observe the expressions of Glypican-3 in hepatocellular carcinoma,paraneoplastic,cirrhosis and normal tissue so as to observe its relationship to clinicopathogical characteristics in hepatocellular carcinoma( HCC),and to provide the prognosis evaluation in HCC. Methods Immunohistochemistry was used on the screened 43 cases of patients with hepatocellular carcinoma to detect the expression of Glypican-3 in hepatocellular carcinoma,cirrhosis and normal controls,carcinoma tissues according to their clinical and pathological data while analyzing the GPC3 and AFP positive expression rate in hepatocellular carcinoma( HCC). Results 1. Expression of GPC3 in tumor was significantly higher than those in paraneoplastic,cirrhosis and normal tissue.( P 0. 05) 2. GPC3 expressions in carcinoma tissues were correlated with differentiation( P 0. 05). 3. Compared with AFP,GPC3 was more sensitive for the immunohistochemistry diagnosis of HCC( P 0. 05). Conclusion 1. Compared with the wildly used immune marker AFP,GPC3 is more sensitive and could be used as a new immune marker for the immunohistochemistry diagnosis and differential diagnosis of HCC. 2. GPC3 may be related to the differentiation of tumor cells.