抗原呈递
抗原处理
抗原
细胞生物学
MHC限制
MHC I级
抗原提呈细胞
主要组织相容性复合体
生物
MHC II级
内吞作用
T细胞
免疫学
细胞
免疫系统
遗传学
作者
Marine Bretou,Anita Kumari,Odile Malbec,Hélène D. Moreau,Dorian Obino,Paolo Pierobon,Violaine Randrian,Pablo J. Sáez,Ana-María Lennon-Duménil
摘要
Antigen presentation refers to the ability of cells to show MHC-associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide-derived antigens that are internalized by endocytosis in antigen-presenting cells (APCs). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APCs: dendritic cells (DCs) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC-T cell interactions. We further discuss how the interaction between APC-specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space.
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