The Features and Molecular Regulation Mechanisms of the Circadian Rhythm of Blood Pressure

The normal blood pressure show obvious the features of circadian rhythm.Significant relationship was found between abnormal blood pressure circadian rhythm,target-organ damage of hypertension and cardiovascular incidient,this kind of abnor-mal blood pressure circadian rhythm was important pathogenic factor,which was independent of blood pressure level.The production and maintenance of blood pressure circadian rhythm was associated with clock gene periodic expression.Bmal1,per2 are key genes in biological clock system operation,its expression level and rhythmic change directly adjust the pressure circadian rhythm.